CATS

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Introduction

The knowledge of the genome structure of the domestic cat is constantly evolving.

Few laboratories around the world have long been engaged in completing the feline genome sequencing, which is essential for the identification of genes responsible for genetically transmitted diseases, morphological characters (such as coat colours) and to understand the origin of breeds or genetic lines. 

Currently, through the development of the map and sequence are known many "genetic markers" on DNA, especially microsatellites and SNPs. Microsatellites are specific points of DNA, mainly used for individual profiling and parentage certification. To evaluate the efficacy and efficiency of these analysis and to harmonise at international level such certifications, an International Comparison test is organised every two years involving the certifying laboratories. Microsatellites have also been used so far for the analysis of genetic variability and inbreeding

SNPs can be employed as genetic markers with the same purposes as microsatellites, but their best application today is on the study of causative genes both for diseases and morpho-traits by high-throughput DNA analysis . Among genetic testing for hereditary feline diseases now available Vetogene can offer Polycystic Kidney Disease (PKD), prevalent in the Persian breed, Hypertrophic Cardiomyopathy (HCM) in Maine Coon and Ragdoll, Blood Type, Spinal Muscolar Atrophy (SMA) and Glicogenosis IV. Other genetic test are available on phenotypic single gene traits such as “gloves” for Birmans, “long hair” and “dilution”.

VetoGene provides also the biological sample storage facility. That is a useful tool for genetic traceability of animals constitutes a database and a biological bank for breeders and owners and it is a precious source of information and templates for future research..


For informations:

Prof.ssa Maria Longeri: maria.longeri@unimi.it